Joint work, conducted in association with Professor Arshad Majid, between AF ChemPharm and Sheffield Institute for Translational Neuroscience SITraN.
The issue of antibiotic resistance as a concern is well-acknowledged globally. AF ChemPharm, through a KTP scheme in collaboration with the University of Sheffield, and also a three-year prestigious Marie Curie European grant (Industry-Academia Pathways and Partnerships IAPP), using advance in sillico design identified a number of pharmacophores as a new generation of antibiotics. Synthesis and initial testing of these compounds showed activity against a number of bacteria. Currently lead optimisation is being pursued.
Indigo is a difficult compound to work with due to its poor solubility in most solvents and its low affinity for cotton. It requires a complex and time-consuming dyeing process which uses large amounts of water and produces waste products that cannot be cheaply recycled. AF ChemPharm was awarded the project by VF a major US corporation to find solutions to the technical challenges of working with indigo which led to a substantial international patent with AF Chempharm’s scientists as co-inventors
Demonstrating our capability and expertise, AF ChemPharm took on the challenge of producing a Kg of a precursor for GMP production of a 12 step drug candidate required for a clinical study for medium size bio-tech company.
Our case studies showcase AF ChemPharm depth of expertise and our range of organic chemistry, contract research services and custom synthesis services. Read and enjoy.